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Appleby et al published a systematic review of the literature from all available studies and concluded that there was compelling evidence for the relative efficacy and safety of IDET.

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The topiramate can be administered in an extended release formulation, by mouth, as a skin patch, ointment or nasal spray.

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Of the remaining 171 patients, zolmitriptan produced significantly higher headache response rates than placebo at 1-hour post-dose (58.

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Consider the benefits and the risks of topiramate when prescribing this drug to women of childbearing potential, particularly when topiramate is considered for a condition not usually associated with permanent injury or death.

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Topiramate is a newer antiepileptic drug that blocks sodium channels, similar to carbamazepine and valproate, and also potentiates γ-aminobutyric acid (GABA) neuroinhibition, similar to valproate.

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Bowden CL, DiClemente C, Roache JD, Lawson K, Javors MA, MA JZ: Oral Topiramate in the treatment of alcohol dependence: a randomised controlled trial.

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Conventional treatments for neuropathic pain, including anticonvulsants, may be appropriate for trial use in specific cases when nervous system structures are symptomatic and for myofascial pain, which may also be a spine-mediated disorder.

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Emphasis is placed on the notion that these are lifetime goals that will control the impact of migraine and minimize the use of medication, which may result in an overall long term improvement in quality of life, as well as reversing any progressive nature of the disease.

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